(19)
(11) EP 1 033 134 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.09.2007 Bulletin 2007/38

(45) Mention of the grant of the patent:
25.04.2007 Bulletin 2007/17

(21) Application number: 98950411.3

(22) Date of filing: 27.10.1998
(51) International Patent Classification (IPC): 
A61K 38/17(2006.01)
C12N 5/12(2006.01)
G01N 33/53(2006.01)
C12R 1/91(2006.01)
 C12P 21/08(2006.01)
C12N 15/08(2006.01)
G01N 33/577(2006.01)
A61P 9/10(2006.01)
(86) International application number:
PCT/JP1998/004862
(87) International publication number:
WO 1999/021577 (06.05.1999 Gazette 1999/18)

(54)

COMPOSITIONS INHIBITING SMOOTH MUSCLE PROLIFERATION AND METHOD FOR THE DIAGNOSIS OF ARTERIOSCLEROSIS

COMPOSITIONS ZUR INHIBIERUNG DER PROLIFERATION GLATTER MUSKULATUR UND VERFAHREN ZUR DIAGNOSE VON ARTERIOSKLEROSE

COMPOSITIONS INHIBANT LA PROLIFERATION DES MUSCLES LISSES ET PROCEDE DE DIAGNOSTIC DE L'ARTERIOSCLEROSE

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 29.10.1997 JP 29756997

(43) Date of publication of application:
06.09.2000 Bulletin 2000/36

(73) Proprietor: OTSUKA PHARMACEUTICAL CO., LTD.
Chiyoda-ku, Tokyo 101-0048 (JP)

(72) Inventors:
  • MATSUZAWA, Yuji
    Takarazuka-shi, Hyogo 665-0804 (JP)
  • OHMOTO, Yasukazu
    Itano-gun Tokushima 771-0219 (JP)

(74) Representative: Marsh, Roy David et al
Hoffmann Eitle, Patent- und Rechtsanwälte Postfach 81 04 20
81904 München
81904 München (DE)


(56) References cited: : 
WO-A2-96/39429
   
  • MAEDA K. et al., "cDNA Cloning and Expression of a Novel Adipose Specific Collagen-Like Factor, apM1 (Adipose Most Abundant Gene Transcript 1)", BIOCHEM. BIOPHYS. RES. COMMUN., 221, 1996, pages 286-289, XP002922055.
  • DATABASE CAPLUS ON STN INTERNATIONAL, DN 129:243192, HIROSHI KURIYAMA et al., "Visceral Fat Syndrome (in Japanese)"; & STRIDES OF MEDICINE, 185(9), May 1998, pages 587-591, XP002922056.
  • DATABASE CAPLUS ON STN INTERNATIONAL, DN 130:33509, KAZUHISA MAEDA, "Body Mapping of Fat Cells (in Japanese)"; THE JOURNAL OF CLINICAL CHEMISTRY, 34(8), August 1998, pages 1027-1033.
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).