(19)

(11)

EP 1 034 176 A1

(12)

(43) Date of publication: 13.09.2000 Bulletin 2000/37 (21) Application number: 98961128.0 (22) Date of filing: 27.10.1998

(51) International Patent Classification (IPC)7: C07D 413/14, C07D 417/14, C07D 413/12, C07D 417/12, A61K 31/42, A61K 31/425 (86) International application number: PCT/EP9806/993 (87) International publication number: WO 9928/316 (10.06.1999 Gazette 1999/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.11.1997 GB 9725138 (71) Applicant: PHARMACIA & UPJOHN S.p.A. 20152 Milano (IT)	(72) Inventors: PEVARELLO, Paolo I-27100 Pavia (IT) VARASI, Mario I-20100 Milano (IT) HEIDEMPERGHER, Franco I-20015 Parabiago (IT) TOMA, Salvatore I-20146 Milano (IT) SPECIALE, Carmela I-20014 Nerviano (IT)