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(11)

EP 1 034 178 A1

(12)

(43) Date of publication: 13.09.2000 Bulletin 2000/37 (21) Application number: 97948592.7 (22) Date of filing: 24.11.1997

(51) International Patent Classification (IPC)7: C07F 9/117, A61K 31/66 (86) International application number: PCT/US9721/931 (87) International publication number: WO 9926/953 (03.06.1999 Gazette 1999/22)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: CLARION PHARMACEUTICALS, INC. Madison, WI 53719 (US)	(72) Inventors: PETERSON, Andrew, C. Madison, WI 53717 (US) YAZDI, Parvin, T. Madison, WI 53715 (US) (74) Representative: Jehan, Robert et al Williams, Powell & Associates,4 St Paul's Churchyard London EC4M 8AY London EC4M 8AY (GB)