(19)

(11)

EP 1 034 263 A1

(12)

(43) Date of publication: 13.09.2000 Bulletin 2000/37 (21) Application number: 98955851.5 (22) Date of filing: 24.11.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 5/10, C07K 16/18, A01K 67/027 (86) International application number: PCT/IB9801/959 (87) International publication number: WO 9927/093 (03.06.1999 Gazette 1999/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.11.1997 US 66649 P 27.08.1998 US 98159 P (71) Applicants: THE UNIVERSITY OF MANITOBA Winnipeg,Manitoba R3E 0W3 (CA) Manitoba Cancer Treatment & Research Foundation Winnipeg,Manitoba R3E 0V9 (CA)	(72) Inventor: GREENBERG, Arnold, H. Winnipeg, Manitoba R3M 0E8 (CA) (74) Representative: Austin, Hedley William et al Urquhart-Dykes & LordAlexandra House1 Alexandra Road SwanseaWales SA1 5ED SwanseaWales SA1 5ED (GB)