(19)

(11)

EP 1 036 171 A2

(12)

(88) Date of publication A3: 12.08.1999 (43) Date of publication: 20.09.2000 Bulletin 2000/38 (21) Application number: 98958401.6 (22) Date of filing: 03.12.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, A61K 38/17, C12Q 1/68, C12N 1/19, C12N 1/21 (86) International application number: PCT/NL9800/687 (87) International publication number: WO 9928/460 (10.06.1999 Gazette 1999/23)

(84) Designated Contracting States: AT BE CH DE ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 03.12.1997 EP 97203781 (71) Applicant: Leadd B.V. 2333 AL Leiden (NL)	(72) Inventors: NOTEBORN, Mathieu, Hubertus, Maria NL-2352 EH Leiderdorp (NL) DANEN-VAN OORSCHOT, Astrid, Adriana, Anna, Maria NL-2651 VG Berkel en Rodenrijs (NL) (74) Representative: Prins, Adrianus Willem  Vereenigde,Nieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)