(19)

(11)

EP 1 036 201 A2

(12)

(88) Date of publication A3: 26.08.1999 (43) Date of publication: 20.09.2000 Bulletin 2000/38 (21) Application number: 98963108.0 (22) Date of filing: 11.12.1998

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US9826/432 (87) International publication number: WO 9929/905 (17.06.1999 Gazette 1999/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.12.1997 US 69434 (71) Applicant: Intergen Company Purchase, NY 10577 (US)	(72) Inventors: JAMES, William, M. Darnestown, MD 20878 (US) NAZARENKO, Irina, A. Gaithersburg, MD 20878 (US) (74) Representative: Plougmann, Vingtoft & Partners A/S  Sankt Annae Plads 11,P.O. Box 3007 1021 Copenhagen K 1021 Copenhagen K (DK)