(19)

(11)

EP 1 037 878 A2

(12)

(88) Date of publication A3: 21.10.1999 (43) Date of publication: 27.09.2000 Bulletin 2000/39 (21) Application number: 98959535.0 (22) Date of filing: 20.11.1998

(51) International Patent Classification (IPC)7: C07D 215/38, C07D 241/44, C07D 277/72, A61K 31/47, A61K 31/495, A61K 31/425 (86) International application number: PCT/US9824/833 (87) International publication number: WO 9926/927 (03.06.1999 Gazette 1999/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.11.1997 US 66758 P (71) Applicant: NPS PHARMACEUTICALS, INC. Salt Lake CityUtah 84108 (US)

(72) Inventors: VAN WAGENEN, Bradford, C. Salt Lake City, UT 84124 (US) MOE, Scott, T. Salt Lake City, UT 84121 (US) SMITH, Daryl, L. Salt Lake City, UT 84121 (US) SHEEHAN, Susan, M. Salt Lake City, UT 84108 (US) SHCHERBAKOVA, Irina Salt Lake City, UT 84103 (US) TRAVATO, Richard Salt Lake City, UT 84117 (US) WALTON, Ruth Ogden, UT 84403 (US) BARMORE, Robert Salt Lake City, UT 84102 (US) DELMAR, Eric, G. Salt Lake City, UT 84108 (US) STORMANN, Thomas, M. Salt Lake City, UT 84105 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing.  Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)