(19)

(11)

EP 1 037 910 A2

(12)

(88) Date of publication A3: 05.08.1999 (43) Date of publication: 27.09.2000 Bulletin 2000/39 (21) Application number: 98961838.4 (22) Date of filing: 30.11.1998

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/US9825/398 (87) International publication number: WO 9928/341 (10.06.1999 Gazette 1999/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.12.1997 US 67690 P (71) Applicant: CREATIVE BIOMOLECULES, INC. Hopkinton, MA 01748 (US)	(72) Inventors: NAKAOKA, TakashiFourth Dept. of Internal Med. Bunkyo-kuTokyo 112 (JP) MIYAZONO, KoheiDept. of Biochem.The Cancer Inst. Toshima-ku,Tokyo 170 (JP) SAMPATH, Kuber, T. Medway, MA 02053 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)