(19)

(11)

EP 1 037 919 A1

(12)

(43) Date of publication: 27.09.2000 Bulletin 2000/39 (21) Application number: 98964142.8 (22) Date of filing: 18.12.1998

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 14/435, A61K 38/17 (86) International application number: PCT/US9827/108 (87) International publication number: WO 9931/135 (24.06.1999 Gazette 1999/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.12.1997 US 993432 (71) Applicants: Tsai, David Westlake Village, CA 91316 (US) Yu, Jenny Westlake Village, CA 91316 (US)	(72) Inventors: Tsai, David Westlake Village, CA 91316 (US) Yu, Jenny Westlake Village, CA 91316 (US) (74) Representative: Tollett, Ian et al Williams, Powell & Associates,4 St. Paul's Churchyard Inn London EC4M 8AY London EC4M 8AY (GB)