(19)

(11)

EP 1 037 969 A1

(12)

(43) Date of publication: 27.09.2000 Bulletin 2000/39 (21) Application number: 98963813.5 (22) Date of filing: 09.12.1998

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 1/21, C12N 15/63, C12N 15/11, C07H 21/04, C07H 21/02, C07K 14/00 (86) International application number: PCT/US9826/086 (87) International publication number: WO 9929/838 (17.06.1999 Gazette 1999/24)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB IE IT LI NL PT SE (30) Priority: 09.12.1997 US 67978 P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Skillman, NJ 08558 (US)	(72) Inventor: CEDERHOLM-WILLIAMS, Stewart, A.,Oxford Biores.rch Oxford OX4 G4GA (GB) (74) Representative: Mays, Julie et al Bristol-Myers Squibb Company,Patent Department,Swakeleys House,Milton Road Ickenham,Uxbridge UB10 8NS Ickenham,Uxbridge UB10 8NS (GB)