(19)

(11)

EP 1 038 020 A1

(12)

(43) Date of publication: 27.09.2000 Bulletin 2000/39 (21) Application number: 98957922.2 (22) Date of filing: 12.11.1998

(51) International Patent Classification (IPC)7: C12P 21/02, A61K 38/17, A61K 38/16, C12N 15/11, C12N 15/00, C12N 15/63, C12N 1/00, C07K 16/00, C12Q 1/68, G01N 33/68 (86) International application number: PCT/US9824/243 (87) International publication number: WO 9924/601 (20.05.1999 Gazette 1999/20)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 12.11.1997 US 65139 P (71) Applicant: SMITHKLINE BECKMAN CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: SOUSA, Silvino North Wales, PA 19454 (US) STOCKWELL, Simon Hertfordshire CM23 5EH (GB) McLAUGHLIN, Megan, M. Drexel Hill, PA 19026 (US) GALLAGHER, Kathleen, Theresa Willow Grove, PA 19090 (US) KIKLY, Kristine, Kay Linfield, PA 19468 (US) (74) Representative: Crump, Julian Richard John et al FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)