(19)

(11)

EP 1 039 927 A1

(12)

(43) Date of publication: 04.10.2000 Bulletin 2000/40 (21) Application number: 98961915.0 (22) Date of filing: 04.12.1998

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/38, A61K 39/02, A61K 39/108, C07H 21/02, C07H 21/04 (86) International application number: PCT/US9825/806 (87) International publication number: WO 9930/735 (24.06.1999 Gazette 1999/25)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 17.12.1997 US 992421 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HUANG, Jianzhong Schwenksville, PA 19473 (US) MCDEVITT, Damien Berwyn, PA 19312 (US) TRAINI, Christopher, M. Media, PA 19063 (US) JIANG, Xinhe Royersford, PA 19468 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)