(19)
(11) EP 1 040 126 A2

(12)

(88) Date of publication A3:
26.08.1999

(43) Date of publication:
04.10.2000 Bulletin 2000/40

(21) Application number: 98964007.3

(22) Date of filing: 16.12.1998
(51) International Patent Classification (IPC)7C07K 14/51, A61K 38/18, C12N 15/86
(86) International application number:
PCT/US9826/788
(87) International publication number:
WO 9931/136 (24.06.1999 Gazette 1999/25)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 17.12.1997 US 69931 P
01.12.1998 US 110498 P

(71) Applicant: CREATIVE BIOMOLECULES, INC.
Hopkinton, MA 01748 (US)

(72) Inventors:
  • SAMPATH, Kuber, T.
    Holliston, MA 01746 (US)
  • COHEN, Charles, M.
    Weston, MA 02193 (US)
  • OEDA, Eiichi
    Ube,Yamaguchi 755-0067 (JP)
  • MIYAZONO, Kohei
    Shiki,Saitama 353-0004 (JP)
  • KAWABATA, Masahiro
    Tokyo 156-0054 (JP)

(74) Representative: Schlich, George William 
Mathys & Squire100 Gray's Inn Road
London WC1X 8AL
London WC1X 8AL (GB)

   


(54) METHODS FOR MAINTAINING OR RESTORING TISSUE-APPROPRIATE PHENOTYPE OF SOFT TISSUE CELLS