(19)
(11) EP 1 040 196 A2

(12)

(88) Date of publication A3:
25.11.1999

(43) Date of publication:
04.10.2000 Bulletin 2000/40

(21) Application number: 98964125.3

(22) Date of filing: 18.12.1998
(51) International Patent Classification (IPC)7C12N 15/57, C12N 9/64, C12N 5/10, A01K 67/027, A61K 49/00
(86) International application number:
PCT/US9827/056
(87) International publication number:
WO 9931/969 (01.07.1999 Gazette 1999/26)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 19.12.1997 US 68312 P
19.12.1997 US 994689

(71) Applicant: AMERICAN HOME PRODUCTS CORPORATION
Madison, New Jersey 07940-0874 (US)

(72) Inventors:
  • NEUHOLD, Lisa, Ann
    Princeton, NJ 08540 (US)
  • KILLAR, Loran, Marie
    Newtown, PA 18940 (US)

(74) Representative: Talbott, Dawn Jacqueline et al
Wyeth Laboratories,Patent Department,Huntercombe Lane South,Taplow
Maidenhead,Berkshire SL6 0PH
Maidenhead,Berkshire SL6 0PH (GB)

   


(54) TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE