(19)

(11)

EP 1 041 882 A1

(12)

(43) Date of publication: 11.10.2000 Bulletin 2000/41 (21) Application number: 98966022.0 (22) Date of filing: 18.12.1998

(51) International Patent Classification (IPC)7: A01N 43/04, A61K 38/00, C07H 21/04, C07K 14/475 (86) International application number: PCT/US9827/072 (87) International publication number: WO 9931/982 (01.07.1999 Gazette 1999/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.12.1997 US 68317 P (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Philadelphia,Pennsylvania 19104-3147 (US)	(72) Inventors: STEDMAN, Hansell, H. Ambler, PA 19002 (US) BRIDGES, Charles, R. Villanova, PA 19085 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)