(19)

(11)

EP 1 042 353 A1

(12)

(43) Date of publication: 11.10.2000 Bulletin 2000/41 (21) Application number: 98965821.6 (22) Date of filing: 11.12.1998

(51) International Patent Classification (IPC)7: C07J 7/00, A61K 31/57, C07J 9/00, A61K 31/575, C07J 51/00 (86) International application number: PCT/EP9808/130 (87) International publication number: WO 9932/506 (01.07.1999 Gazette 1999/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.12.1997 EP 97203998 (71) Applicant: Akzo Nobel N.V. 6824 BM Arnhem (NL)	(72) Inventors: HEIJMANS, Christian NL-4823 HB Breda (NL) VAN DER LOUW, Jaap NL-5345 EN Oss (NL) (74) Representative: Kraak, Hajo et al N.V. Organon,Postbus 20 5340 BH Oss 5340 BH Oss (NL)