(19)

(11)

EP 1 042 465 A1

(12)

(43) Date of publication: 11.10.2000 Bulletin 2000/41 (21) Application number: 98959647.3 (22) Date of filing: 01.12.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/00 (86) International application number: PCT/US9825/454 (87) International publication number: WO 9928/467 (10.06.1999 Gazette 1999/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.12.1997 US 984638 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: SHEPPARD, Paul, O. Redmond, WA 98053 (US) DEISHER, Theresa, A. Seattle, WA 98115 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)