(19)

(11)

EP 1 042 472 A1

(12)

(43) Date of publication: 11.10.2000 Bulletin 2000/41 (21) Application number: 98964942.1 (22) Date of filing: 23.12.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/715, C07K 16/28, G01N 27/447 (86) International application number: PCT/US9827/625 (87) International publication number: WO 9932/629 (01.07.1999 Gazette 1999/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.12.1997 US 68634 P (71) Applicant: IMMUNEX CORPORATION SeattleWashington 98101 (US)	(72) Inventor: SIMS, John, Ernest Seattle, WA 98103 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)