(19)

(11)

EP 1 042 725 A1

(12)

(43) Date of publication: 11.10.2000 Bulletin 2000/41 (21) Application number: 98963250.0 (22) Date of filing: 16.12.1998

(51) International Patent Classification (IPC)7: G06G 7/48, C07K 1/00, C07K 14/00, C07K 16/00, C07K 17/00 (86) International application number: PCT/US9826/783 (87) International publication number: WO 9931/616 (24.06.1999 Gazette 1999/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.12.1997 US 69727 P (71) Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE CambridgeMassachusetts 02138 (US)	(72) Inventors: OLSEN, Bjorn, R. Milton, MA 02186 (US) HOHENESTER, Erhard London N4 4RP (GB) TIMPL, Rupert D-82131 Gauting (DE) SASAKI, Takako D-81377 Munchen (DE) (74) Representative: Dzieglewska, Hanna Eva et al Frank B. Dehn & Co.,European Patent Attorneys,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)