(19)

(11)

EP 1 043 980 A2

(12)

(88) Date of publication A3: 02.09.1999 (43) Date of publication: 18.10.2000 Bulletin 2000/42 (21) Application number: 98953826.9 (22) Date of filing: 26.10.1998

(51) International Patent Classification (IPC)7: A61K 31/00 (86) International application number: PCT/US9822/255 (87) International publication number: WO 9921/540 (06.05.1999 Gazette 1999/18)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 28.10.1997 US 959213 (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)	(72) Inventors: COFFIN, Vicki Basking Ridge, NJ 07920 (US) GLUE, Paul, W. Flemington, NJ 08822 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)