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EP 1 044 187 A1

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(43) Date of publication: 18.10.2000 Bulletin 2000/42 (21) Application number: 98959050.0 (22) Date of filing: 11.12.1998

(51) International Patent Classification (IPC)7: C07D 213/56, A61K 31/44, C07D 215/14, C07D 237/08, C07D 239/26, C07D 241/12, A61K 31/50, A61K 31/505, A61K 31/495 (86) International application number: PCT/GB9803/712 (87) International publication number: WO 9931/065 (24.06.1999 Gazette 1999/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.12.1997 US 989353 07.12.1998 US 206245 (71) Applicants: Cell Pathways, Inc. Horsham,Pennsylvania 19044 (US) THE UNIVERSITY OF ARIZONA Tucson,Arizona 85721 (US)	(72) Inventors: SPERL, Gerhard North Wales, PA 19454 (US) GROSS, Paul Stockton, CA 95211 (US) BRENDEL, Klaus Tucson, AZ 85715 (US) PIAZZA, Gary Doylestown, PA 18901 (US) PAMUKCU, Rifat Spring House, PA 19477 (US) (74) Representative: Baverstock, Michael George Douglas et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)