(19)

(11)

EP 1 044 217 A2

(12)

(88) Date of publication A3: 10.09.1999 (43) Date of publication: 18.10.2000 Bulletin 2000/42 (21) Application number: 98963962.0 (22) Date of filing: 15.12.1998

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/US9826/705 (87) International publication number: WO 9932/514 (01.07.1999 Gazette 1999/26)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.12.1997 US 68179 P 11.09.1998 US 99840 P (71) Applicant: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US)	(72) Inventor: SUN, Yi Ann Arbor, MI 48105 (US) (74) Representative: Mansmann, Ivo  Warner-Lambert Company,Legal Division,Legal Department,c/o Gödecke AG 79090 Freiburg 79090 Freiburg (DE)