(19)

(11)

EP 1 044 267 A2

(12)

(88) Date of publication A3: 10.09.1999 (43) Date of publication: 18.10.2000 Bulletin 2000/42 (21) Application number: 98966103.8 (22) Date of filing: 28.12.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C12N 5/10, C12N 1/21, C12N 1/19, C07K 14/705, C07K 16/28, A61K 38/17, A61K 39/395, G01N 33/53, G01N 33/68 (86) International application number: PCT/US9827/688 (87) International publication number: WO 9933/967 (08.07.1999 Gazette 1999/27)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.12.1997 US 68925 P (71) Applicant: REGENERON PHARMACEUTICALS, INC. Tarrytown, NY 10591-6707 (US)	(72) Inventor: VALENZUELA, David, M. Yorktown Heights, NY 10598 (US) (74) Representative: Goldin, Douglas Michael et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)