(19)

(11)

EP 1 045 860 A2

(12)

(88) Date of publication A3: 07.10.1999 (43) Date of publication: 25.10.2000 Bulletin 2000/43 (21) Application number: 99903019.0 (22) Date of filing: 08.01.1999

(51) International Patent Classification (IPC)7: C07K 14/62, G01N 33/68 (86) International application number: PCT/US9900/471 (87) International publication number: WO 9935/169 (15.07.1999 Gazette 1999/28)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.01.1998 US 70821 P (71) Applicants: Duckworth, William Clifford Omaha, NE 68112 (US) Hamel, Frederick G. Omaha, NE 68124 (US)	(72) Inventors: Duckworth, William Clifford Omaha, NE 68112 (US) Hamel, Frederick G. Omaha, NE 68124 (US) (74) Representative: Hubert, Philippe et al Cabinet Beau de Loménie158, rue de l'Université 75340 Paris Cédex 07 75340 Paris Cédex 07 (FR)