(19)
(11) EP 1 045 920 A1

(12)

(43) Date of publication:
25.10.2000 Bulletin 2000/43

(21) Application number: 99901457.4

(22) Date of filing: 13.01.1999
(51) International Patent Classification (IPC)7C12N 15/86, C12N 15/34, C12N 15/38, C12N 5/10, A61K 48/00
(86) International application number:
PCT/US9900/733
(87) International publication number:
WO 9936/562 (22.07.1999 Gazette 1999/29)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 14.01.1998 US 71409 P

(71) Applicant: Human Gene Therapy Research Institute
Des Moines, IA 50309 (US)

(72) Inventors:
  • RADOSEVICH, Thomas, J.
    Des Moines, IA 50309 (US)
  • LINK, Charles, J., Jr.
    Des Moines, IA 50309 (US)

(74) Representative: Thomson, Paul Anthony et al
Potts, Kerr & Co.15, Hamilton Square
BirkenheadMerseyside L41 6BR
BirkenheadMerseyside L41 6BR (GB)

   


(54) NUCLEOTIDE EXPRESSION SYSTEMS WITH REDUCED IMMUNOGENICITY FOR USE IN GENE THERAPY