Methods and reagents for very large scale immobilized polymer synthesis

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EP 1 046 421 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	11.01.2006 Bulletin 2006/02

(45)	Mention of the grant of the patent:
	02.07.2003 Bulletin 2003/27

(21)	Application number: 00202667.2

(22)	Date of filing: 20.11.1991

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International Patent Classification (IPC):

B01J 19/00^(1980.01)
C07C 229/14^(1990.01)
C07D 263/44^(1985.01)
C07H 19/04^(1974.07)
G03F 7/00^(1968.09)
G01N 33/543^(1985.01)
G01N 21/64^(1980.01)

C07B 61/00^(1985.01)
C07C 229/16^(1990.01)
C07D 317/62^(1985.01)
C07K 1/04^(1985.01)
G03F 7/26^(1980.01)
G01N 21/25^(1980.01)

(54)	Methods and reagents for very large scale immobilized polymer synthesis Verfahren und Reagenzien für immobilisierten Polymersynthese in sehr grossem Masstab Procédé et réactifs poul la synthèse immobilisée de polymères à très grande échelle

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

06.12.1990 US 624120

(43)	Date of publication of application:
	25.10.2000 Bulletin 2000/43

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	92903279.5 / 0562025

(73)	Proprietor: Affymetrix, Inc. (a Delaware Corporation)
	Santa Clara, CA 95051 (US)

(72)	Inventors:
	Fodor, Stephen P.A. Palo Alto, CA 94303 (US) Stryer, Lubert Stanford, CA 94305 (US) Winkler, James L. Sunnyvale, CA 94086 (US) Holmes, Christopher W. Saratoga, CA 95070 (US) Solas, Dennis W. San Francisco, CA 94131 (US)

(74)	Representative: Williams, Richard Andrew Norman et al
	HLBBshaw Merlin House Falconry Court Bakers Lane Epping, Essex CM16 5DQ Epping, Essex CM16 5DQ (GB)

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References cited: :

EP-A- 0 046 430
EP-A- 0 233 403
EP-A- 0 400 920
WO-A-90/15070
US-A- 4 269 933
US-A- 4 478 967

EP-A- 0 194 132
EP-A- 0 266 881
WO-A-87/05942
DE-A- 2 612 359
US-A- 4 477 556
US-A- 4 715 929

RONALD FRANK ET AL.: "FACILE AND RAPID 'SPOT-SYNTHESIS' OF LARGE NUMBERS OF PEPTIDES ON MEMBRANE SHEETS" 1991 , PROCEEDINGS OF THE 21ST EUROPEAN PEPTIDE SYMPOSIUM, PLATJA D'ORO, SPAIN, 2-8 SEPTEMBER 1990 , LEIDEN, NL XP000353583 190790 * the whole document *
V. K. HARIDASAN & V. N. RAJASEKHARAN PILLAI: "PEPTIDE SYNTHESIS USING PHOTOLYTICALLY CLEAVABLE 2-NITROBENZYLOXYCARBONYL PROTECTING GROUP" PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY. PART A. PHYSICAL SCIENCES, vol. 53, no. 6, November 1987 (1987-11), pages 717-728, XP000961323 NEW DEHLI,IN ISSN: 0370-0046
V. N. RAJASEKHARAN PILLAI: "Photoremovable Protecting Groups in Organic Synthesis" SYNTHESIS, vol. 1, no. 1, 1980, pages 1-26, XP002099233 STUTTGART, DE ISSN: 0039-7881
PATENT ABSTRACTS OF JAPAN vol. 13, no. 557 (P-974), 12 December 1989 (1989-12-12) -& JP 01 233447 A (OKI ELECTRIC IND. CO. LTD.), 19 September 1989 (1989-09-19) -& DATABASE WPI Section Ch, Week 8943 Derwent Publications Ltd., London, GB; Class A08, AN 89-314201 XP002154030 & JP 01 233447 A (OKI ELECTRIC IND. K.K.), 19 September 1989 (1989-09-19)
E. REICHMANIS ET AL.: "o-Nitrobenzyl Photochemistry: Solution vs. Solid-State Behaviour" JOURNAL OF POLYMER SCIENCE, POLYMER CHEMISTRY EDITION, vol. 23, no. 1, January 1985 (1985-01), pages 1-8, XP002154027 NEW YORK US
MICHIKO IWAMURA ET AL.: "1-pyrenyl esters, photolabile protectong groups for carboxylic acids" TETRAHEDRON LETTERS, vol. 28, no. 6, 1987, pages 679-682, XP001010146 ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL ISSN: 0040-4039
PATENT ABSTRACTS OF JAPAN vol. 014, no. 340 (P-1080), 23 July 1990 (1990-07-23) & JP 02 116735 A (SUZUKI MOTOR CO LTD), 1 May 1990 (1990-05-01) & DE 40 13 588 A (SUZUKI JIDOSHA KOGYO K.K.) 14 November 1991 (1991-11-14) & DATABASE WPI Section Ch, Week 199023 Derwent Publications Ltd., London, GB; Class B04, AN 1990-175880 & JP 02 116735 A (SUZUKI MOTOR CORP.), 1 May 1990 (1990-05-01)

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