(19)

(11)

EP 1 047 457 A2

(12)

(88) Date of publication A3: 10.02.2000 (43) Date of publication: 02.11.2000 Bulletin 2000/44 (21) Application number: 99917293.5 (22) Date of filing: 15.01.1999

(51) International Patent Classification (IPC)7: A61K 51/10, A61K 47/48, A61K 31/385 (86) International application number: PCT/US9900/857 (87) International publication number: WO 9936/105 (22.07.1999 Gazette 1999/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.01.1998 US 8620 (71) Applicants: MCA Development B.V. 9747 AN Groningen (NL) Borchardt, Paul E. Denton, TX 76205 (US) Vriesendorp, Huibert, M. Houston, TX 77005-3755 (US) Quadri, Syed M. Potomac, MA 20854 (US)	(72) Inventors: BORCHARDT, Paul, E. Denton, TX 76205 (US) VRIESENDORP, Huibert, M. Houston, TX 77005-3755 (US) QUADRI, Syed, M. Potomac, MA 20854 (US) (74) Representative: Stevens, Ian Edward et al Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)