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(11)

EP 1 047 670 A1

(12)

(43) Date of publication: 02.11.2000 Bulletin 2000/44 (21) Application number: 99901722.1 (22) Date of filing: 13.01.1999

(51) International Patent Classification (IPC)7: C07C 311/16, C07D 207/09, C07D 217/06, C07D 295/12, C07D 295/18, C07D 295/22, A61K 31/18 (86) International application number: PCT/GB9900/099 (87) International publication number: WO 9936/398 (22.07.1999 Gazette 1999/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 14.01.1998 GB 9800750 (71) Applicant: ELI LILLY AND COMPANY LIMITED Basingstoke,Hants RG21 6XA (GB)	(72) Inventors: MILUTINOVIC, Sandra Reading,Berkshire RG2 7DX (GB) SIMMONDS, Robin, George Wokingham,Berkshire RG41 3JD (GB) TUPPER, David, Edward Reading,Berkshire RG6 3AT (GB) (74) Representative: Hudson, Christopher Mark et al Lilly Industries LimitedEuropean Patent OperationsErl Wood Manor WindleshamSurrey GU20 6PH WindleshamSurrey GU20 6PH (GB)