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EP 1 049 472 A1

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(43) Date of publication: 08.11.2000 Bulletin 2000/45 (21) Application number: 98955082.7 (22) Date of filing: 23.10.1998

(51) International Patent Classification (IPC)7: A61K 31/47, A61K 31/445, A61K 31/405, A61K 31/38, A61K 31/35, C07D 209/04, C07D 209/14, C07D 333/52, C07D 409/14, C07D 401/10, C07D 401/14, C07D 405/10, C07D 405/14, C07D 409/10, C07D 217/02, C07D 217/12 (86) International application number: PCT/US9822/487 (87) International publication number: WO 9921/557 (06.05.1999 Gazette 1999/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.10.1997 US 63312 P 27.03.1998 GB 9806694 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: CHU, Lin Rahway, NJ 07065 (US) GOULET, Mark, T. Rahway, NJ 07065 (US) WALSH, Thomas, F. Rahway, NJ 07065 (US) WITKIN, Stephanie, L. Rahway, NJ 07065 (US) WYVRATT, Matthew, J. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)