(19)
(11) EP 1 049 677 A1

(12)

(43) Date of publication:
08.11.2000 Bulletin 2000/45

(21) Application number: 99904789.7

(22) Date of filing: 16.01.1999
(51) International Patent Classification (IPC)7: C07D 239/16, C07C 311/19, A61K 31/505
(86) International application number:
PCT/EP9900/242
(87) International publication number:
WO 9937/621 (29.07.1999 Gazette 1999/30)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 23.01.1998 US 12489

(71) Applicants:
  • Aventis Pharma Deutschland GmbH
    65929 Frankfurt am Main (DE)
  • Genentech, Inc.
    South San Francisco, CA 94080-4990 (US)

(72) Inventors:
  • PEYMAN, Anuschirwan
    D-65779 Kelkheim (DE)
  • WILL, David, William
    D-65824 Schwalbach (DE)
  • KNOLLE, Jochen
    D-65830 Kriftel (DE)
  • SCHEUNEMANN, Karlheinz
    D-65835 Liederbach (DE)
  • CARNIATO, Denis
    F-91460 Marcoussis (FR)
  • GOURVEST, Jean-François
    F-77410 Claye Souilly (FR)
  • GADEK, Thomas
    Oakland, CA 94611 (US)
  • MCDOWELL, Robert
    San Francisco, CA 94114 (US)
  • BODARY, Sarah, Catherine
    San Bruno, CA 94066 (US)
  • CUTHBERTSON, Robert, Andrew
    North Fitzroy, VIC 3068 (AU)

(74) Representative: Vieillefosse, Jean-Claude et al
Hoechst Marion RousselDépartement des Brevets102, Route de Noisy
93235 Romainville Cedex
93235 Romainville Cedex (FR)

   


(54) NOVEL SULFONAMIDE DERIVATIVES AS INHIBITORS OF BONE RESORPTION AND AS INHIBITORS OF CELL ADHESION