(19)

(11)

EP 1 049 708 A1

(12)

(43) Date of publication: 08.11.2000 Bulletin 2000/45 (21) Application number: 99904190.8 (22) Date of filing: 22.01.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 14/47, C12N 15/63, C12N 1/21, C12N 15/85 (86) International application number: PCT/US9901/313 (87) International publication number: WO 9937/660 (29.07.1999 Gazette 1999/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.01.1998 US 72298 P 28.08.1998 US 98539 P (71) Applicants: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US) Beth Israel Deaconess Medical Center Boston, MA 02215 (US)	(72) Inventors: IRUELA-ARISPE, Luisa Los Angeles, CA 90024 (US) HASTINGS, Gregg, A. Thousand Oaks, CA 91320 (US) RUBEN, Steven, M. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)