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EP 1 049 776 A1

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(43) Date of publication: 08.11.2000 Bulletin 2000/45 (21) Application number: 99902425.0 (22) Date of filing: 21.01.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/435, C07K 14/47, C12N 5/10, C07K 16/18, C12Q 1/68, G01N 33/53, A61K 38/17, A01K 67/027 (86) International application number: PCT/US9901/361 (87) International publication number: WO 9937/770 (29.07.1999 Gazette 1999/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.01.1998 US 82324 P 11.06.1998 US 96731 11.06.1998 US 96347 11.06.1998 GB 9812660 24.09.1998 GB 9820816 (71) Applicants: COLD SPRING HARBOR LABORATORY Cold Spring HarborNew York 11724 (US) Devgen N.V. 9052 Zwijnaarde (BE)	(72) Inventors: LIU, Qiong Hauppauge, NY 11788 (US) HENGARTNER, Michael O.,Cold Spring Harbor Lab. Cold Spring Harbor, NY 11724 24 (US) BOGAERT, Thierry, Andre, Oliver, Eddy B-8500 Kortrijk (BE) VAN CRIEKINGE, Wim, Maria, Rene B-2500 Kontich (BE) (74) Representative: Roques, Sarah Elizabeth et al J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)