(19)

(11)

EP 1 049 799 A1

(12)

(43) Date of publication: 08.11.2000 Bulletin 2000/45 (21) Application number: 99903262.6 (22) Date of filing: 22.01.1999

(51) International Patent Classification (IPC)7: C12Q 1/18, G01N 33/94, G01N 33/68, C12N 15/53, C12N 9/02, C07K 14/31, C07K 16/40, A61K 38/43, C12Q 1/68, G01N 33/573 (86) International application number: PCT/US9901/288 (87) International publication number: WO 9937/800 (29.07.1999 Gazette 1999/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.01.1998 US 72244 P 26.01.1998 US 13440 (71) Applicant: TRUSTEES OF TUFTS COLLEGE Medford, MA 02155 (US)	(72) Inventors: LEVY, Stuart, B. Boston, MA 02116 (US) McMURRY, Laura, M. Somerville, MA 02145 (US) (74) Representative: Plougmann, Vingtoft & Partners A/S  Sankt Annae Plads 11,P.O. Box 3007 1021 Copenhagen K 1021 Copenhagen K (DK)