(19)

(11)

EP 1 051 429 A1

(12)

(43) Date of publication: 15.11.2000 Bulletin 2000/46 (21) Application number: 99971425.6 (22) Date of filing: 27.10.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C12N 1/21, C12N 15/00, C12N 15/63, C07K 14/705, G01N 33/53, C12Q 1/68 (86) International application number: PCT/US9925/178 (87) International publication number: WO 0026/227 (11.05.2000 Gazette 2000/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.10.1998 US 183175 (71) Applicant: Millennium Pharmaceuticals, Inc. Cambridge,Massachusetts 02139 (US)	(72) Inventor: MCCARTHY, Sean, A. Boston, MA 02116 (US) (74) Representative: Schüssler, Andrea, Dr.  Kanzlei Huber & SchüsslerTruderinger Strasse 246 81825 München 81825 München (DE)