(19)

(11)

EP 1 051 488 A2

(12)

(88) Date of publication A3: 25.11.1999 (43) Date of publication: 15.11.2000 Bulletin 2000/46 (21) Application number: 99902197.5 (22) Date of filing: 12.01.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/475, A61K 38/18, C07K 16/22, C12Q 1/68 (86) International application number: PCT/US9900/654 (87) International publication number: WO 9938/976 (05.08.1999 Gazette 1999/31)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 29.01.1998 US 15412 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto, CA 94304 (US)	(72) Inventors: HILLMAN, Jennifer, L. Mountain View, CA 94040 (US) LAL, Preeti Santa Clara, CA 95054 (US) CORLEY, Neil, C. Mountain View, CA 94040 (US) BAUGHN, Mariah San Leandro, CA 94577 (US) GUEGLER, Karl, J. Menlo Park, CA 94025 (US) TANG, Y., Tom San Jose, CA 95118 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)