(19)

(11)

EP 1 051 499 A2

(12)

(88) Date of publication A3: 30.03.2000 (43) Date of publication: 15.11.2000 Bulletin 2000/46 (21) Application number: 99904344.1 (22) Date of filing: 28.01.1999

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/10, C12N 5/10, C12N 1/21, C07K 14/47, C07K 16/40, G01N 33/53 (86) International application number: PCT/US9901/756 (87) International publication number: WO 9938/980 (05.08.1999 Gazette 1999/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.01.1998 US 72994 P 09.09.1998 US 150133 09.09.1998 US 150141 (71) Applicant: The Board of Regents of the University of Oklahoma Norman, OK 78019 (US)	(72) Inventor: MOORE, Kevin, L. Oklahoma City, OK 73118 (US) (74) Representative: Ebner von Eschenbach, Jennifer et al c/o Ladas & Parry,Dachauerstrasse 37 80335 München 80335 München (DE)