(19)

(11)

EP 1 051 508 A1

(12)

(43) Date of publication: 15.11.2000 Bulletin 2000/46 (21) Application number: 99902185.0 (22) Date of filing: 12.01.1999

(51) International Patent Classification (IPC)7: C12Q 1/00, C12N 9/12, C12N 15/00, C12N 5/00, C12N 1/20, C07H 21/04, C07K 16/00 (86) International application number: PCT/US9900/623 (87) International publication number: WO 9938/994 (05.08.1999 Gazette 1999/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 29.01.1998 US 73031 P 25.11.1998 US 109992 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventor: SHI, Yuguang Carmel, IN 46033 (US) (74) Representative: Denholm, Anna Marie et al Eli Lilly and Company Limited,Lilly Research Center,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)