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EP 1 052 992 A1

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(43) Date of publication: 22.11.2000 Bulletin 2000/47 (21) Application number: 99906697.0 (22) Date of filing: 01.02.1999

(51) International Patent Classification (IPC)7: A61K 31/445, A61K 31/535, A61K 31/54, A61K 31/55, C07D 211/18, C07D 211/32, C07D 211/36, C07D 211/96, C07D 401/06, C07D 401/14, C07D 407/14, C07D 409/10, C07D 409/14, C07D 413/14, C07D 417/14, C07D 471/10, C07D 491/107 (86) International application number: PCT/US9902/165 (87) International publication number: WO 9938/514 (05.08.1999 Gazette 1999/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.02.1998 US 73446 P 20.05.1998 GB 9810890 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)

(72) Inventors: CALDWELL, Charles, G. Rahway, NJ 07065 (US) FINKE, Paul, E. Rahway, NJ 07065 (US) MACCOSS, Malcolm Rahway, NJ 07065 (US) MILLS, Sander, G. Rahway, NJ 07065 (US) OATES, Bryan Rahway, NJ 07065 (US) KIM, Dooseop Rahway, NJ 07065 (US) KOTHANDARAMAN, Shankaran Rahway, NJ 07065 (US) WANG, Liping Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James et al European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)