(19)

(11)

EP 1 053 005 A2

(12)

(88) Date of publication A3: 30.09.1999 (43) Date of publication: 22.11.2000 Bulletin 2000/47 (21) Application number: 99905876.1 (22) Date of filing: 08.02.1999

(51) International Patent Classification (IPC)7: A61K 38/08 (86) International application number: PCT/US9902/725 (87) International publication number: WO 9940/107 (12.08.1999 Gazette 1999/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.02.1998 US 74105 P (71) Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles, CA 90007-4344 (US)	(72) Inventors: RODGERS, Kathleen, E. Long Beach, CA 90815 (US) DIZEREGA, Gere Pasadena, CA 91106 (US) (74) Representative: Grund, Martin et al Dr. Volker VossiusPatentanwaltskanzleiHolbeinstrasse 5 81679 München 81679 München (DE)