(19)

(11)

EP 1 054 865 A1

(12)

(43) Date of publication: 29.11.2000 Bulletin 2000/48 (21) Application number: 99903834.2 (22) Date of filing: 04.02.1999

(51) International Patent Classification (IPC)7: C07D 207/12, A61K 31/395, C07D 403/12, C07D 231/12, C07D 417/06, C07D 401/12, C07D 417/12 (86) International application number: PCT/GB9900/369 (87) International publication number: WO 9941/235 (19.08.1999 Gazette 1999/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.02.1998 EP 98400294 (71) Applicants: AstraZeneca UK Limited London W1Y 6LN (GB) ZENECA Pharma S.A. 95022 Cergy Pontoise Cédex (FR)	(72) Inventors: DRAKE, David John Macclesfield,Cheshire SK10 4TG (GB) WARDLEWORTH, James Michael Macclesfield,Cheshire SK10 4TG (GB) (74) Representative: Tinsley, Rachel Maria  AstraZeneca UK Limited,Global Intellectual Property Patents,P.O. Box 272,Mereside,Alderley Park Macclesfield,Cheshire SK10 4TG Macclesfield,Cheshire SK10 4TG (GB)