(19)

(11)

EP 1 054 957 A1

(12)

(43) Date of publication: 29.11.2000 Bulletin 2000/48 (21) Application number: 99903592.6 (22) Date of filing: 15.02.1999

(51) International Patent Classification (IPC)7: C12N 9/28 // C11D3:386 (86) International application number: PCT/DK9900/066 (87) International publication number: WO 9942/567 (26.08.1999 Gazette 1999/34)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 18.02.1998 DK 22898 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: OUTTRUP, Helle DK-2880 Bagsvaerd (DK) NIELSEN, Bjarne, Roenfeldt DK-2880 Bagsvaerd (DK) HEDEGAARD, Lisbeth DK-2880 Bagsvaerd (DK) ANDERSEN, Jens, Toenne DK-2880 Bagsvaerd (DK)