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(11)

EP 1 054 967 A1

(12)

(43) Date of publication: 29.11.2000 Bulletin 2000/48 (21) Application number: 99909515.1 (22) Date of filing: 19.02.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/475, C12N 15/86, C12N 5/10, C07K 16/22, C07K 16/42, G01N 33/53, C12Q 1/68 (86) International application number: PCT/US9903/585 (87) International publication number: WO 9942/583 (26.08.1999 Gazette 1999/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.02.1998 US 27405 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: SHEPPARD, Paul, O. Redmond, WA 98053 (US) JASPERS, Stephen, R. Edmonds, WA 98026 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)