(19)

(11)

EP 1 056 466 A1

(12)

(43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99909502.9 (22) Date of filing: 18.02.1999

(51) International Patent Classification (IPC)7: A61K 38/00, C07K 5/00, C07K 7/00, C07K 16/00, C07K 17/00, C07H 21/04, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74, C12P 21/06, C12Q 1/68 (86) International application number: PCT/US9903/436 (87) International publication number: WO 9942/120 (26.08.1999 Gazette 1999/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.02.1998 US 27337 (71) Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS Little Rock, AR 72207-3608 (US)	(72) Inventors: O'BRIEN, Timothy, J. Little Rock, AR 72227 (US) TANIMOTO, Hirotoshi Little Rock, AR 72211 (US) (74) Representative: Wilkinson, Stephen John et al Stevens, Hewlett & Perkins1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)