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EP 1 056 468 A1

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(43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99907048.5 (22) Date of filing: 16.02.1999

(51) International Patent Classification (IPC)7: A61K 38/08, C07K 7/14, C12N 5/06, C12N 5/08, C12N 5/00 (86) International application number: PCT/US9903/243 (87) International publication number: WO 9942/122 (26.08.1999 Gazette 1999/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.02.1998 US 75179 P (71) Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles, CA 90007-4344 (US)	(72) Inventors: RODGERS, Kathleen, E. Long Beach, CA 90815 (US) DIZEREGA, Gere Pasadena, CA 91106 (US) (74) Representative: Grund, Martin et al Dr. Volker VossiusPatentanwaltskanzleiHolbeinstrasse 5 81679 München 81679 München (DE)