(19)

(11)

EP 1 056 471 A1

(12)

(43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99901309.7 (22) Date of filing: 06.01.1999

(51) International Patent Classification (IPC)7: A61K 39/395, C07K 16/42 (86) International application number: PCT/US9900/135 (87) International publication number: WO 9938/531 (05.08.1999 Gazette 1999/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.01.1998 US 15269 29.01.1998 US 73033 P (71) Applicant: Tanox, Inc. Houston, TX 77025 (US)	(72) Inventor: CHANG, Tse, Wen,National Tsing Hua University Hsin-Chu, 300 (TW) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)