(19)

(11)

EP 1 056 719 A2

(12)

(88) Date of publication A3: 16.12.1999 (43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99908379.3 (22) Date of filing: 24.02.1999

(51) International Patent Classification (IPC)7: C07D 209/00 (86) International application number: PCT/US9903/899 (87) International publication number: WO 9943/651 (02.09.1999 Gazette 1999/35)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 25.02.1998 US 30062 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)

(72) Inventors: SEEHRA, Jasbir, S. Lexington, MA 02173 (US) KAILA, Neelu Natick, MA 01760 (US) MCKEW, John, C. Arlington, MA 02474 (US) LOVERING, Frank Acton, MA 01720 (US) BEMIS, Jean, E. Arlington, MA 02174 (US) XIANG, YiBin Acton, MA 01720 (US) (74) Representative: Wileman, David Francis, Dr.  c/o Wyeth LaboratoriesHuntercombe Lane South TaplowMaidenheadBerkshire SL6 OPH TaplowMaidenheadBerkshire SL6 OPH (GB)