(19)

(11)

EP 1 056 762 A1

(12)

(43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99904381.3 (22) Date of filing: 28.01.1999

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C12N 15/51, C12N 5/10, C12N 15/85, A61K 39/12, A61K 39/29 (86) International application number: PCT/US9901/823 (87) International publication number: WO 9938/880 (05.08.1999 Gazette 1999/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 30.01.1998 US 73156 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02114 (US)	(72) Inventors: WANDS, Jack Waban, MA 02168 (US) ENCKE, Jens Boston, MA 02114 (US) (74) Representative: Ablett, Graham Keith et al Ablett & Stebbing,Caparo House,101-103 Baker Street London W1M 1FD London W1M 1FD (GB)