(19)

(11)

EP 1 056 846 A1

(12)

(43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99905108.9 (22) Date of filing: 22.02.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/63, C07K 14/00, C07K 16/18, C12Q 1/68, G01N 33/68 (86) International application number: PCT/GB9900/534 (87) International publication number: WO 9942/576 (26.08.1999 Gazette 1999/34)

(84) Designated Contracting States: BE CH CY DE DK FR GB IT LI NL (30) Priority: 23.02.1998 GB 9803786 22.01.1999 GB 9901463 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventor: BARNES, Michael, Robert,SmithKline Beecham Phar. Harlow, Essex CM19 5AW (GB) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)