(19)

(11)

EP 1 056 854 A2

(12)

(88) Date of publication A3: 14.10.1999 (43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99906934.7 (22) Date of filing: 11.02.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 9/74, C07K 16/28, C12N 1/21, C12N 1/19, C12N 5/10, C12Q 1/00, G01N 33/68, A61K 38/48, A61K 38/17 (86) International application number: PCT/US9902/983 (87) International publication number: WO 9943/809 (02.09.1999 Gazette 1999/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.02.1998 US 32397 (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: COUGHLIN, Shaun, R. Tiburon, CA 94920 (US) KAHN, Mark Burlingame, CA 94010 (US) (74) Representative: Goldin, Douglas Michael et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)