(19)

(11)

EP 1 056 871 A1

(12)

(43) Date of publication: 06.12.2000 Bulletin 2000/49 (21) Application number: 99910252.8 (22) Date of filing: 23.02.1999

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 9/64, C12N 1/21, C12N 1/19, C12N 5/10, C07K 16/40, C12Q 1/37, C12Q 1/68 (86) International application number: PCT/EP9901/132 (87) International publication number: WO 9943/831 (02.09.1999 Gazette 1999/35)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 25.02.1998 GB 9804010 11.12.1998 GB 9827425 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: EVANS, Joanne, Rachel,SmithKline Beecham Pharma. Harlow,Essex CM19 5AW (GB) SELZER, Paul, Maria,SmithKline Beecham Pharma. Harlow,Essex CM19 5AW (GB) SOUTHAN, Christopher D.,SmithKline Beecham Pharma Harlow,Essex CM19 5AW (GB) (74) Representative: Crump, Julian Richard John et al FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)